Objective: To compare the efects of Shangke Jiegu tablet and Jianbu Huqian pill on postoperative rehabilitation of patients with Lisfranc joint injury. Method: Sixty-eight Lisfranc joint injury patients were selected from October 2010 to May 2012 in our hospital. The patients were randomly divided into Shangke Jiegu tablet group and Jianbu Huqian pill group of 34 patients each. All patients were treated with open reduction and internal fixation surgery. The patients in Shangke Jiegu plate group received 4 Shangke Jiegu tablets three times daily. The patients in Jianbu Huqian pill group received 10 Jianbu Huqian pills twice daily. The postoperative evaluation of foot function

the time of clinical symptom improvement

callus X-ray scores at different time and adverse events of the Lisfranc joint injury patients in two groups were compared and analyzed. Result: Compared with Jianbu Huqian pill group

the overall excellent ratio of foot function was significantly increased (73.53%)

the disappear time of clinical symptoms including swelling and tenderness (5.58±2.41) d and (10.64±2.43) d was reduced significantly in Shangke Jiegu plate group. The VAS score of (1.51±1.02) points was reduced significantly after treatment. The callus X-ray scores at 14

21 d and 28 d were (0.78±0.09) points

(1.34±0.25) points

(2.51±0.42) points

respectively

which were significantly improved (P<0.05). Conclusion: Shangke Jiegu tablet could promote the efficacy of postoperative rehabilitation of Lisfranc joint injury. It could be an safe and effective medicine for adjuvant therapy and it is worthy to be applied widely in clinic.