Objective: To observe the clinical efficacy of Yiqi Tongqiao decoction in the treatment of acute cerebral infarction (ACI)

and determine its effect on serum peroxisome proliferator activated receptor gamma (PPAR-γ) level. Method: Seventy ACI patients were randomly divided into treatment group and observation group. Patients in two groups were given conventional treatment

and patients in the treatment group added Yiqi Tongqiao decoction. The patients in both groups received a 4-week period of treatment. Changes of China stroke scale (CSS) score

clinical symptom score and serum PPAR-γ level were observed before and after treatment. Result: ①Thirty patients in both groups completed the study. Clinical efficacy of the treatment group was 86.7%

which was higher than 73.3% of the observation group. ②Serum PPAR-γ in patients with ACI was obviously higher than that of the control group (P<0.01).③After treatment

clinical symptom score

CSS score and serum PPAR-γ level of two groups were significantly decreased (P<0.01)

and the results in treatment group were better than those in the observation group (P<0.01). ④After treatment fasting plasma glucose(FBG)

triglycerides (TG)

total cholesterol (TC) of the treatment group decreased significantly (P<0.01)

while the observation group had no significant change. Conclusion: Using conventional therapy plus Yiqi Tongqiao decoction have remarkable curative effect in treating ACI. Dynamic monitoring serum PPAR-γ level is conducive to assess the effect and progression in treating ACI.