Objective: To discuss the short-term curative efficacy of Liangxue Xiaoyin decoction in treating psoriasis vulgaris at active stage (blood heat syndrome) and its adjusting function on T-cell subset in peripheral blood and inflammatory factor. Method: Ninety-five patients were randomly divided into control group (46 cases) and observation group (49 cases) by random number table. Patients in both groups received tazarotene gel by external use

and patients in control group added 4 Fufang Qingdai capsules 3 times daily

patients in observation group added dialectical therapy of Liangxue Xiaoyin decoction 1 dose daily. Patients in two groups received a 8 week period of treatment. Scores of lesion size of skin

psoriasis area and severity index (PASI) and itch degree were graded by visual analogue scale (VAS) before and after 2

4 and 8-week treatment. Scores of dermatology life quality index (DLQI) and teat in blood system were graded

and levels of T-cell subset in peripheral blood and serous interleukin-6 (IL-6)

interleukin-17 (IL-17) and tumor necrosis factor-α(TNF-α) were detected before and after treatment. Result: The clinical effect in observation group was superior to that in control group by Ridit analysis (P<0.05). Score of PASI in observation group was lower than that in control group after 8-week treatment (P<0.01)

and VAS score of itch degree in observation group was lower than that in control group after 4 and 8-week treatment (P<0.01). Scores of DLQI and heat in blood system in observation group were lower than those in control group (P<0.01). Levels of CD3+

CD4+

CD4+/CD8+ in both groups were increased as compared with those before treatment

while the observation group gained higher results (P<0.01). Level of CD8+ in both group was decreased as compared with that before treatment

while the observation group gained lower result (P<0.01). After treatment

levels of serum IL-6

IL-17 and TNF-α in observation group were inferior to those in control group (P<0.01). Result: Using Liangxue Xiaoyin decoction orally combined Tazarotene gel externally could control psoriasis vulgaris during active stage (blood heat syndrome) patients with psoriasis skin lesions and stabilize the disease situation. The mechanism may be related to regulating imbalance of peripheral blood T cell subsets and reducing proinflammatory medium.