Objective: To optimize processing technology of wine Paeoniae Radix Alba and provide a reference for clinical medication of this herb. Method: HPLC was employed to determine the content of paeoniflorin with mobile phase of acetonitrile-0.1% phosphoric acid(14:86) and detection wavelength of 230 nm.Taking appearance

contents of paeoniflorin and water-soluble extract as comprehensive evaluation index

orthogonal test was adopted to investigate effects of the dosage of yellow rice wine

temperature and time on processing technology. Result: The best processing conditions were 10% dosage of yellow rice wine

processing temperature of 90℃ and processing time of 15 min.Wine Paeoniae Radix Alba was slightly yellowish with slightly wine aroma

mass fractions of paeoniflorin and water-soluble extract were 3.79% and 37.51%

respectively. Conclusion: Appearance is an important index for evaluation of quality criteria of Chinese medicine pieces.This optimized processing technology is stable

feasible and applicable to industrial production of wine Paeoniae Radix Alba through comprehensive scoring method.