Objective: To study the effect of Ailuo Kechuanning on levels of soluble intercellular adhesion molecular-1(sICAM-1)

tumor necrosis factor alpha(TNF-α)

interleukin-8(IL-8)

interleukin-17(IL-17) and C-reactive protein(CRP) in serum

bronchial alveolar lavage fluid (BALF) and lung homogenates of rats with chronic obstructive pulmonary disease (COPD). Method: The method of smoke add drops of bacteria preparation was used to rat model COPD with stabilization and acute aggravatin.the rats were randomly divided into normal control group

model group

Ailuo Kechuanning group (7.75

15.52

31.04 g·kg-1·d-1)

ELISA was used to determine the levels of sICAM-1

TNF-α

IL-8

IL-17 and CRP in serum

BALF and lung homogenates. Result: ①Stable period:the total number of neutrophils and inflammatory cells were significantly increased (P<0.01) in BALF.The levels of sICAM-1

TNF-α

IL-8

IL-17 and CRP in serum

BALF and lung homogenates of the stable period model group were significantly higher than those in normal control group. While the levels of sICAM-1

TNF-α

IL-8

IL-17 and CRP were decreased significantly in serum

BALF and lung homogenates of the rats treated with Ailuo Kechuanning(15.52 g·kg-1·d-1)than those in stable period model group.②Acute exacerbation of COPD:the obvervational index changes direction in acute exacerbation period tend to be consistent with stabilization period. Conclusion: The mechanism of Ailuo Kechuanning anti-inflammatory may reduce the number of neutrophils and macrophages

and decrease the levels of sICAM-1

TNF-α

IL-8

IL-17 and CRP.