Objective: To compare effects of brucine and brucine-hydroxypropyl-β-cyclodextrin(bru-HP-β-CD) inclusion complex on adjuvant-induced arthritis rats

in order to provide a reference for development of this preparation. Method: After being modeled with Freund's complete adjuvant

effects of brucine and bru-HP-β-CD inclusion complex on pharmacological indexes of adjuvant arthritis rats were detected

including primary and secondary voix pedis swelling

pain threshold

weight and so on. Result: Compared with the model group

brucine group and bru-HP-β-CD inclusion complex group could significantly increase pain threshold and reduce voix pedis swelling.Analgesic effect was the best after proinflammatory for 0.5 h by brucine

its anti-inflammatory effect for primary disease after 48 h was the most significant;however

analgesic effect was optimum after proinflammatory for 1.0 h by bru-HP-β-CD inclusion complex

its anti-inflammatory effects were better than those of brucine group for primary disease after 72 h and secondary disease after 24 d. Conclusion: Anti-inflammatory effect of brucine is rapid action

but effect of bru-HP-β-CD can maintain for a long time and is better than brucine.Brucine can effectively relieve joint pain of rats with adjuvant-induced arthritis after being included by HP-β-CD

and has sustained and promoting effect.