Objective: To discuss the curative efficacy of Shenqi Fuzheng injection united meglumine adenosine cyclphosphate in treating chronic heart failure (CHF) and to investigate its influence on troponin T(cTnT)

insulin-like growth factor 1(IGF-1) and homocysteine (HCY). Method: Eighty-six patients with CHF were randomly divided into control group (43 cases) and observation group (43 cases). Patients in both groups received conventional non-drug and drug therapies. Drug therapy included 25-50 mg hydrochlorothiazide tablets

12.5 mg captopril tablets

50-100 mg metoprolol tartrate tablets twice daily

and 0.25 mg digoxin tablets once daily when needed. Patients in control group received intravenous drip of 120 mL meglumine adenosine cyclphosphate injection once daily. Based on the treatment of control group

patients in observation group added intravenous drip of 250 mL Senqi Fuzheng injection and 120 mg mixture meglumine adenosine cyclphosphate once daily. Patients in two groups received 2-week treatment. Cardiac function was tested by adopt echocardiogram before and after treatment. Levels of N terminal pro-brain natriuretic peptide (NT-proBNP)

cTnT

IGF-1 and HCY were detected before and after treatment. Result: By Ridit analysis

the curative effect of observation group was superior to that of control group (P<0.05). The levels of left ventricular ejection fraction(LVEF)

output per mimute(CO) and stroke volume(SV) of observation group were higher than those of control group (P<0.01). Levels of NT-proBNP

cTnT and HCY in observation group were less than those in control group (P<0.01)

while the IGF-1 of observation group was superior to that of control group (P<0.01). Conclusion: Using Senqi Fuzheng injection combined with meglumine adenosine cyclphosphate could enhance the levels of LVEF

CO

SV in CHF patients and improve heart function significantly. Its mechanism may related to improving IGF-1 level and reduce the NT-proBNP

cTnT and HCY levels.