Objective: To investigate therapeutic effects of Nostoc commune powder on blood glucose of type 2 diabetic rats. Method: Type 2 diabetic rats model was established by intraperitoneal injection of streptozotocin(STZ

35 mg · kg-1) on SD rats after rats were fed with high sugar and high fat for 4 weeks.These rats were divided into 6 models

included low dose group(N. commune powder 25 mg · kg-1)

middle dose group(N. commune powder 50 mg · kg-1)

high dose group(N. commune powder 100 mg · kg-1)

positive group(metformin hydrochloride 200 mg · kg-1)

model group(physiological saline 200 mg · kg-1) and normal group.After 6 weeks of administration

indexes of body weight

fasting blood glucose

total quality of micturition and defecation and water intake were measured. Result: After 6 weeks of administration

compared with the model group

body weight of diabetic rats were significantly increased in low

middle and high dose group

blood glucose and total quality of micturition and defecation

water intake levels of three dose groups of diabetic rats were significantly decreased;these indexes had significant differences among these three dose groups.Effects between positive control groups and three N. commune powder groups were statistically nonsignificant on these four indexes. Conclusion: N. commune powder can reduce blood glucose levels of experimental rats with type 2 diabetes mellitus by intraperitoneal injection of STZ

and effect of hypoglycemic is positively correlated by N. commune powder concentrations.