Objective: To prepare the dragon's blood gels and to investigate its effect of wound tissue repair in mice. Method: The orthogonal experiment was designed with carbomer concentration

propylene glycol volume and pH value as factors

the appearance

irritation

thermostability

chill stability and centrifug stabiity as evaluation index to optimize the best formula of dragon's blood gels. Thirty mice were randomly divided into 3 groups

the model group (gels base)

the observation group (dragon's blood gels) and the positive drug group (clindamycin lidocaine gels). The trauma was made by cuting a size of the diameter of 1.2 cm wound in the back of the mice. The wound changes at different time points were observed and the histopathological score of wound biopsy was evaluated. Result: The preparation of dragon's blood gel was optimized as follows:0.5% Carbomer-940

2.5 mL Propylene glycol and adjusting pH to 8.0.The product displayed a predominant spread property with uniform appearance and color. No changes of product were observed after the thermostability

chill stability and eentrifug stabiity tests. The mice tests showed that the wound surface was more smooth and neat

and the heal time was shorter in the dragon's blood gels and positive drug groups than those in the model group with significiant difference (P<0.05). Conclusion: The preparation technology of dragon's blood gels is simple and the gel has good stability. Morever

the dragon's blood gels could promote the tissue repair in mice.