Objective: To observe the total flavone of hawthorn leaf (TFHL) on apoptosis of cerebral ischemia reperfusion injury in rats and c-fos

c-jun the effects of gene expression. Method: Eighty SD rats were randomly divided into sham group

model group

TFHL 70 mg · kg-1 group

140 mg · kg-1group and Yinxingye tablet 3.5 mg · kg-1 group

and each group of 16. Four blood vessel blocking method to establish the whole cerebral ischemia reperfusion injury model of shuttle box test to detect the ability of learning and memory;spectrophotometric assay superoxide dismutase (SOD)activity and malondialdehyde(MDA) content;enzyme-linked immunosorbent assay (ELISA) method to detect the content of caspase-3;immunohistochemical method to detect c-jun and the expression of c-fos. Result: Compared with sham group

model group rats learning and memory ability

active rats escape response rate significantly decreased (P<0.01)

Brain tissue apoptosis cells increased significantly (P<0.01);c-fos and c-jun gene expression obviously increased (P<0.01). Compared with model group

TFHL active escape response rate and Yinxingye tablet group rats increased (P<0.05)

SOD activity was significantly increased (P<0.05)

MDA content was significantly lower(P<0.05)

apoptotic cells decreased significantly (P<0.05)

c-fos and c-jun gene expression decreased significantly (P<0.05). Conclusion: TFHL can reducing cerebral ischemia reperfusion injury of brain tissue c-fos and c-jun gene expression

inhibition of neural cell apoptosis

improving cerebral ischemia-reperfusion injury in rats of nerve function

improve the learning and memory ability of rats.