Objective: To discuss the curative efficacy of Jiedu Yukui decoction cooperated with conventional western medicine therapy in treating erosive oral lichen planus (OLP) and to investigate its influence on serous tumor necrosis factor-α (TNF-α)

and interleukin-2

4

10 (IL-2

4

10). Method: Eighty eligible patients were randomly divided into control group (40 cases) and traditional Chinese combined western medicine group (40 cases) according to the order of being in hospital. Patients in control group received compound chlorhexidine gargle thrice daily for 2 weeks

1 mL triamcinolone acetonide combined with 2 mL 2% lidocaine submucosally local injection for 4 weeks

and vitamin A

C orally for 12 weeks. Based on the treatment of control group

patients in traditional Chinese combined western medicine group added dialectical modified Jiedu Yukui decoction for 12 weeks. The objective index and signs

subjective symptoms and quality of life were evaluated before and after 4 weeks of treatment. The levels of TNF-α and IL-2

4

10 were detected before and after 12 weeks of treatment. Result: The clinical effect in traditional Chinese combined western medicine group was superior to that in control group (P<0.05). After 4 weeks

scores of objective index and signs

subjective symptoms and quality of life were decreased

and the change was more obvious in traditional Chinese combined western medicine group as compared with before (P<0.01). Levels of TNF-α and IL-2

4

10 in traditional Chinese combined western medicine group were less than those in control group after 12 weeks of treatment (P<0.01). Recurrence rate was 22.5% in traditional Chinese combined western medicine group

which was lower than 45% in control group (P<0.05). Conclusion: Jiedu Yukui decoction cooperated with conventional western medicine therapy could relieve the symptoms of patients

improve their quality of lives and clinical effect

and reduce the recurrence in treating erosive oral lichen planus. Its mechanism of action may be related to regulating the inflammatory response induced by T cell.