Objective: To explore the influence of endothelial function and blood rheology in diabetic rats by paeonol and tanshinol. Method: Diabetic model was established by streptozotocin

the modeling 40 rats were randomly divided into model group

paeonol group(2.5 mg·kg-1

ig)

tanshinol group(5 mg·kg-1

ig)

paeonol combined with tanshinol group. Another 10 healthy rats were taken as normal control group

normal group and model group mice were given distilled water

the administration lasted 8 weeks. Body weight

blood sugar

the endothelial function and hemorheology index changes of rats were determined. Result: ①Compared with model group

there was no significant difference for the blood sugar in the phenol group

tanshinol group and combined group

compared with normal group

there was no significant difference. ②Compared with normal group

nitric oxide(NO)

endothelin(ET-1)

von Willebrand's factor(vWF) and plasminogen astivator inhibitor-1(PAI-1) were increased in model group (P<0.05)

after 8 weeks treatment

compared with model group

there were no significant difference for vWF and NO in the phenol group

tanshinol group

NO in combined group significantly increased (P<0.05)

vWF decreased (P<0.05);there were no significant for ET-1 in the phenol group

and ET-1 of tanshinol group and combined group significantly increased (P<0.05). There were significant difference for PAI-1 in the phenol group

tanshinol group and combined group(P<0.05);fibrinogen(Fg) in the phenol group had no significant differences

and Fg in tanshinol group and combined group had significant difference (P<0.05). ③Compared with normal group

in model group

whole blood low shear viscosity

whole blood high shear viscosity

plasma viscosity

erythrocyte and fibrin deposition pressure had significant difference (P<0.05). Compared with model group

the whole blood viscosity and high and low shear in the phenol group

tanshinol group and combined group were significantly lower (P<0.05)

red blood cells were significantly lower (P<0.05)

red blood cells of deposited in joint group were higher than that of group (P<0.05). Fibrous protein in tanshinol group and combined group was significantly lower than that of model group (P<0.05). Conclusion: Paeonol combined with tanshinol can improve the blood rheology of experimental diabetic rats

has certain protective effect on endothelial function of diabetic rats.