Objective: To screen the effective parts of Echinopsis Radix through bacteriostasis and anti-inflammatory activities. Method: Echinopsis Radix was firstly extracted by ethanol

and followed by petroleum ether

chloroform

ethyl acetate

and n-butanol to obtaine the different parts of extraction. Mice were randomly divided into blank group

aspirin group (0.11 g·kg-1)

and high-

low-dose of different extraction parts groups. The anti-inflammatory activity of different solvent extraction parts of Echinopsis Radix was examined by xylene-induced ear swelling mice. The effects against Staphylococcus aureus

Escherichia coli

Bacillus subtilis

Salmonella typhimurium

and Pseudomonas aeruginosa were examined by scraping line method and tube dilution method. Result: The chloroform extraction part of Echinopsis Radix showed an inhibition rate of higher than 60% in ear swelling mice

while the effect of the other extraction parts was very weak. The ethyl acetate extraction part showed the lowest MIC against S. aureus and B. subtilis (312.5 g·L-1)

while the n-butanol extraction part showed the lowest MIC against S. aureus and P. aeruginosa (312.5 g·L-1). Conclusion: It shows that the chloroform extraction is the anti-inflammatory part of Echinopsis Radix

the ethyl acetate extraction and n-butanol extraction are the bacteriostatic parts. It provides the evidence for the further development and utilization of Echinopsis Radix.