Objective: To explore the molecular mechanisms of Changweiqing in treating colon cancer invasion and metastasis. Method: The experiment included the blank group

the low-

medium-

high-dose Changweiqing groups (0.98

1.97

3.93 g·L-1)

the oxaliplatin group(9.23 mg·L-1)

and the combination group (1.97 g·L-1 Changweiqing plus 9.23 mg·L-1 oxaliplatin). The colon cancer LoVo cells were used in this study. The mRNA and protein of E-cadherin

Wint/beta chain protein signaling pathway factor β-catenin and matrix metalloproteinase-7 (MMP-7) were detected by RT-qPCR and Western blot assay. Result: Compared to the blank group

the mRNA

protein expression of E-cadherin increased

the mRNA expression of β-catenin and MMP-7 decreased in LoVo cells at all doses of Changweiqing groups

oxaliplatin group and combined group (P<0.05

P<0.01). Meanwhile

the results were better in the combination group. Conclusion: Changweiqing has synergetic effect with oxaliplatin by increasing the expression of E-cadherin and enhancing the adhesion between cells

inhibiting Wint/β-catenin signaling pathway activity

decreasing the expression of β-catenin and MMP-7.