Objective: To explore the material basis of Banxia Xiexin Tang in regulating gastrointestinal motility. Method: The two kinds of model were established by subcutaneous injection of atropine sulfate and chronic water immersion stress respectively.Domperidone(0.01 g·kg-1)

Banxia Xiexin Tang(2 g·kg-1)

pungent drugs

bitter drugs and tonic with sweet drugs(1.5 g·kg-1) were orally given for 4 days. The remnant rate of stomach and progradation rate of small intestine were measured. Result: Compared with normal group

the gastric retention rate of model group increased

and the small intestinal propulsion decreased. The difference was statistically significant(P<0.05

P<0.01). When the model rats were orally given different drugs

both of the 2 indicators had different degrees of change. The banxia xiexin decoction decreased the gastric retention rate of the model rats. The ethanol precipitation of Banxia Xiexin Tang

the bitter drugs and the ethanol precipitation of bitter drugs decreased the gastric retention of normal rats and the two kinds of model rats. The difference was statistically significant (P<0.05

P<0.01). Conclusion: Banxia Xiexin Tang may be play the role of regulating gastrointestinal motility

the bitter drugs for purgation are the effective group mainly and the ethanol precipitation parts are the effective components.