Objective: To observe the effects of Butong paste (BT paste) combined with seretide on the lung function and immunologic function in patients with persistent asthma. Method: Before and after 15 days of the fortnightly periods of ‘Beginning of Winter’

105 patients were randomly divided into 3 groups:the combination group

the BT paste group and the seretide group. Patients in the BT paste group received 10 mL BT paste

patients in the seretide group received seretide (50/250)

and patients in the combination group received above two treatments each morning and evening for 3 months. Before and after treatment

asthma control test (ACT) values of three groups were observed

the levels of the first second forced expiratory volume percentage of expected value (FEV1%) and serum interferon-γ (INF-γ)

interleukin 4 (IL-4) in serum were measured. Result: Compared with the other two groups

the levels of ACT value

FEV1%

INF-γ in serum were higher (P<0.05)

while the levels of IL-4 were lower (P<0.05) in the combination group after treatment. Conclusion: The mechanisms of BT paste in the treatment of asthma are involved in IL-4

INF-γ and other aspects. The study also shows that the BT paste combined with seretide has synergetic effect

which could improve the lung function and regulate the immunity in treating persistent asthma. This treatment method is worthy of wide application.