Formulations study of sustained-release drug delivery system has made some progress for Chinese material medica

it is becoming a hotspot issue that to study synchronicity of multiple components release

but complex compositions of Chinese material medica make it difficult to study synchronicity of release.In this paper

recent related literature of studies in synchronous release of multiple components has been collected and analysed for Chinese medicine sustained-release preparations for oral administration

solid dispersion technology

layered preforming technology

multiple coating technology and osmotic pump technology are main technology to control synchronous release

synchronicity evaluation method mainly includes release similarity factor method and combination method of similarity factor and fingerprints.At this stage

control technology of synchronous release has made some achievements

but the degree of synchronous release is not high enough

synchronicity evaluation method is valuable at a certain extent

but not complete and systematic.Research on synchronous release is to absorb advantage of synchronous transport of Chinese material medica decoctions

in order to simulate original maximum effectiveness.At the same time

contrast research of synchronous release with non-synchronous release is still needed to confirm necessity and importance of synchronicity for achieving overall

synchronization and comprehensive action.