Objective: To investigate the effects of Lianxia formula granule (LXFG) on left ventricular remodeling and cardiac function of rats after acute myocardial infarction (AMI). Method: Ninty healthy adult male Wistar rats were randomly assigned to six groups:the sham operated group

the model group

the metoprolol group

the low-

moderate- and high-dose LXFG groups (47.25

94.50

189.00 mg · kg-1). The AMI rats were induced by the ligation of the left anterior descending coronary artery except for rats in the sham operated group. The rats in the sham operated group and model group were given with normal saline

and the other rats received the corresponding medicines by intragastric administration for 30 days. The left ventricular ejection fractions (EF)

factional shortening (FS)

left ventricular mass (LV Mass)

left ventricular end-diastolic volume (LVEDV)

left ventricular end-systolic volume (LVESV)

left ventricular end-diastolic dimension (LVEDD)

left ventricular end-systolic dimension (LVESD)

end diastolic left ventricular posteriol wall thickness (LVPWd) and the end systolic left ventricular posterior wall thickness (LVPWs) of each rat were detected by echocardiogram. Result: Compared with the the model group

EF and FS of LXFG group at 189.00 mg · kg-1 dose enhanced (P<0.05)

and LVEDV

LVESV

LVEDD

LVESD

LV Mass

LVPWd and LVPWs of LXFG group at 189.00 mg · kg-1 dose decreased (P<0.05)

LV Mass and LVPWs of LXFG group at 47.25 mg · kg-1 dose decreased (P<0.05

P<0.01). Compared with the metoprolol group

LV Mass of LXFG group at 189.00 mg · kg-1 dose decreased (P<0.05). Conclusion: Application of LXFG could improve left ventricular remodeling and left ventricular function in rats after AMI.