Objective: To identify the anti-inflammatory active fraction from fruits of Capparis spinosa preliminarily of Uighur medicine. Method: Fruits of Capparis spinosa were extracted by distilled water

80% ethanol and petroleum ether to obtain the different polar fractions groups. Every polar extractions was divided into high

middle

low groups

respectively. The tripterygium glycosides tablet was selected as a positive control drug. The anti-inflammatory active fraction was screened through auricle edema induced by xylene and paw edema induced by carrageen in mice. After 14 days of treatment

the degree of auricle edema and paw edema were measured

the prostaglandin E2 (PGE2) of ankle was detected. Result: The results suggested the foot swelling degree was inhibited

the PGE2 content decreased in the tripterygium glycosides tablet and all extracts groups in xylene-induced auricle edema mice (P <0.05). The paw edema degree was inhibited in the tripterygium glycosides tablet and all extracts groups in carrageen-induced paw edema mice (P <0.05). The distilled water extracts at all doses from Capers fruits had the best results on acute inflammatory reactions than the other groups(P <0.05). Conclusion: Distilled water extracts from Capers fruits have potential anti-inflammation effect. The distilled water extracts may be the anti-inflammatory active fraction from fruits of C. spinosa.