Objective: To observe the impact of Saposhnikoviae Radix of Tongxie Yaofang decoction on peroxisome proliferator-activated receptor (PPAR-γ) protein expression in the ulcerative colitis rats

and to explore the role of Saposhnikoviae Radix. Method: Sixty female SD rats were randomly divided into 6 groups

10 rats in each group. The rat ulcerative colitis(UC) model was made with 50% 2

4

6-trinitrobenzenesulfonic acid(TNBS)ethanol solution.The corresponding prescription without and with Saposhnikoviae Radix

half dose of Saposhnikoviae Radix were orally given

the dose was 18

20

22 g · kg-1

positive group was given salicylazosulfapyridine (SASP) at dose of 0.3 g · kg-1. The weight change

the colon mucosa damage index and colon pathology were observed

and immunohistochemical detection of PPAR-γ protein expression level was carried out. Result: The model group rats had colon mucosa inflammation and ulcer formation

compared with the blank group the result was statistically significant (P<0.05). Expression of PPAR-γ protein in model group rats colon tissue was lower than that in the control group

the difference was statistically significant (P<0.05).After the treatment

PPAR-γ protein expression level in Tongxie Yaofang decoction group was significantly higher than that in groups without or reduced Saposhnikoviae Radix (P<0.05). Conclusion: Saposhnikoviae Radix is minister drug in Tongxie Yaofang decoction

its dosage has significant impact on action of the decoction.