Objective: To investigate effect of Fuling prescription(FLP) on anti-senility of Caenorhabditis elegans. Method: C. elegans were divided into the control group and high dose

medium dose and low dose groups of FLP.Effect of FLP on lifespan of C. elegans was observed by life test

effect of FLP on fertility of C. elegans was detected

acute heat stress and oxidative stress were conducted to test ability of stress-resistance and to explore mechanism of FLP. Result: Average lifes of each group were (19.96±1.48)

(36.03±1.76)

(28.47±1.01)

(19.39±0.61) d

maximum lifespans were (21.01±1.36)

(37.71±2.38)

(29.19±3.12)

(22.00±2.01) d.Compared with the control group

FLP could significantly extend average life

maximum lifespan and lifespan in acute heat stress and oxidative stress environment of C. elegans.But there wAs no significant difference of total subalgebra between the control group and FLP groups. Conclusion: FLP has a remarkable effect of anti-senility

its mechanism may have relation to improvement of stress resistance ability of C. elegans.