Objective: To observe the acutea hepatotoxicity and nephrotoxicity of geniposide on α-naphthylisothiocyanate (ANIT) -induced jaundice rats

and to provide scientific basis for the clinical application of gardenia. Method: One hundred and ninety rats were divided into three following groups:the normal group

the model group and the geniposide group. The alanine aminotransferase (ALT)

aspartic transaminase (AST)

alkaline phosphatase (ALP)

total bilirubin (TBIL)

blood urea nitrogen (BUN) and creatinine (CREA) activity in serum were detected at different time. The morphological changes of liver and kidney tissue were observed under light microscope. Result: Compared with the normal group

the levels of AST

ALP

ALT

TBIL

BUN and CREA increased in the model and geniposide groups. The results in the geniposide group were even worse for AST

ALP and ALT at 48

72 h

for BUN and CREA at 24

48

72 h than the model group. Under light microscope

serious pathological damage in liver and kidney tissue of rats were observed in the model and geniposide groups

which were more serious at 48

72 h. Conclusion: Geniposide could cause acute liver and kidney injury on jaundice rats.