Objective: To observe the effect of Bailong Lingsha Tang (BLLST) on cellular immune function in the treatment of advanced non-small cell lung cancer. Method: Totally 60 patients with advanced non-small cell lung cancer were randomly divided into the control group and the treatment group of 30 patients each. Patients in the control group were treated by routine chemotherapy

while patients in the treatment group were treated by combination of BLLST and routine chemotherapy. Changes of KPS and symptom scores were observed in both groups. Result: Compared with the control group

percentage levels of CD3+

CD4+

CD4+／CD8+

and NK cells increased

percentage levels of CD8+

CD19+decreased in the treatment group with significant difference (P<0.05) after 2-cycle chemotherapy. Improvement of symptoms in the treatment group (86.70%) was higher than that in the control group (56.70%) with significant difference (P<0.05). Improvement of KPS

quality of life in the treated group after treatment was superior to those in the control group with significant difference (P<0.05). Conclusion: Combination of BLLST and chemotherapy could increase the cellular immune function

improve and relax lesions symptoms

and improve the quality of life.