Objective: To observe the influence of Huoxue Ditan decoction on the recovery of neural function and to investigate its mechanism of action in treating hypertensive cerebral hemorrhage disease (HICH). Method: Ninety-four patients with HICH were randomly divided into the control group (47 cases) and the observation group (47 cases) by a random number table. Patients in the control group received Western medicine comprehensive treatment including surgical treatment

dehydration of intracranial pressure

blood pressure control

prevent infection

nerve nutrition and expectant support. Based on the treatment of the control group

patients in the observation group added one does Huoxue Ditan decoction once daily. All patients received 14 days of treatment. The national institutes of health USA nerve function defect (NIHSS) scores and cerebral edema were evaluated before treatment

at day 7

14.Levels of complement C3

C4

hypersensitive c-reactive protein (hs-CRP)

neuropeptide Y (NPY) and serum neuron specific enolization enzyme (NSE) were tested. Result: The clinical curative effect of the observation group was superior to that in the control group (P<0.05). Levels of NPY

NSE and hs-CRP in the observation group were less than those of control group (P<0.01). Compared with before

levels of C3

C4 increased in the control group after treatment (P<0.01). However

changes in the observation group were not obvious. Levels in C3

C4 in the observation group were lower than those in the control group (P<0.01). NIHSS score in the observation group was lower than that in the control group at day 7

14 (P<0.01). Cerebral edema volume in the observation group decreased compared with the data before and seven days after treatment (P<0.01). Ccompared with before and day 7

volume of cerebral edema at day 14 in the observation group went down (P<0.01). Edema volume at day 7

14 in the observation group decreased persistently (P<0.01)

and they were lower than those in control group (P<0.01). Conclusion: Based on the conventional Western medicine comprehensive therapy

Huoxue Ditan decoction could receive edema and improve the recovery of neurological function. Its mechanism of action may be related to reducing the vascular resistance

the inflammatory response and the nerve injury caused by the complement system.