Objective: To discuss the curative efficacy of Tiaochong Xiaozheng decoction in treating hyperplasia of mammary glands and to investigate its influence on endocrinology and endothelin. Method: One hundred and twenty-six patients with hyperplasia of mammary glands were randomly divided into the control group (63 cases) and the observation group (63 cases) by a random number table. Patients in the control group received 4 grains Rubi Sanjie capsules thrice daily. Patients in the observation group received Tiaochong 1 dose Xiaozheng decoction once daily. All patients in two groups received 12 weeks of treatment. Before and after treatment

scores of pain and mass were graded. Contents of estrogen (E2)

prolactin (PRL)

progesterone (P)

testosterone (T)

vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) were detected. Molybdenum target X-ray was detected

and relapse constitution of patients who had curative efficacy was recorded during the 6-month follow-up. Result: The curative efficacy in the observation group was superior to that in the observation group (P<0.05). X-ray molybdenum target photography effect in the observation group was better than that in the control group by ridit analysis (P<0.05). Scores of breast pain

breast tenderness

lump hardness

mass distribution and lump size in the observation group were less than those in the control group after therapy (P<0.01). Levels of E2 and PRL in the observation group were lower than those in the control group (P<0.01)

while the P level was higher than that in the control group (P<0.01). After treatment

serum VEGF and bFGF levels in the observation group were lower to those in the control group (P<0.01). The recurrence rate in the observation group was 27.12%

which was less than 47.06% in the control group (P<0.05). Conclusion: Tiaochong Xiaozheng decoction could reduce pain feeling

soften and narrow the mass

and reduce the recurrence rate with mammary gland hyperplasia disease. Its clinical curative effect is obviously distinct. Its mechanism may be related to regulating endocrine and inhibiting angiogenesis factor.