Objective: To evaluate the effectiveness and safety of Tianma Gouteng Decoction (TGD) combined with angiotensin-converting enzyme inhibitors (ACEI) in treating patients with primary hypertension. Method: Systematic literature searches were performed in Chinese biomedical

China National Knowledge Infrastructure (CNKI) and Wanfang database. Randomised control trials (RCT) about TGD combined with ACEI in treating patients with primary hypertension were enrolled. The quality of the RCT were assessed using Jadad scores. The effectiveness (clinical effect

blood pressure) and safety were evaluated using meta-analysis. Result: A total of 18 articles were included. Only one article scored 3 according to the Jadad

and the others scored less than 3.Compared with ACEI

TGD combined with ACEI had significant higher clinical efficacy [RR=1.18

95% CI (1.12

1.24)]. After treatment

weighted mean difference of systolic blood pressure and diastolic blood pressure were [-4.78

95%CI (-8.35

-1.21)]

and [-4.32 95%CI(-6.34

-2.30)]

respectively. TGD combined with ACEI did not increase the risks for side effect. Conclusion: TGD combined with ACEI has good effectiveness

and there was no increase in the side effect. Therefore

it is recommended in clinical practice. However

it is necessary to carry out high-quality double-blinded RCT with large sample size.