基于方证对应理论的黄连解毒汤肠道吸收分析

谈聪; 薛世姣; 李博; 张启春; 潘林梅; 段金廒; 朱华旭; 郭立玮

doi:10.13422/j.cnki.syfjx.2015050006

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基于方证对应理论的黄连解毒汤肠道吸收分析

药剂与炮制 | 更新时间：2024-01-04

- 基于方证对应理论的黄连解毒汤肠道吸收分析
- Intestinal Absorption Analysis of Huanglian Jiedu Tang Based on Theory of Correspondence Between Syndrome and Prescription
- 中国实验方剂学杂志 2015年21卷第5期页码：6-10
- 作者机构：
- 作者简介：
- 基金信息：
  
  国家自然科学基金项目(81274096,81303230);江苏省科技厅产学研联合创新前瞻性研究项目(BY2012036);江苏省科技支撑计划社会发展项目(BE-2012763);江苏省科技厅自然科学基金项目(BK2012855);江苏省六大人才高峰项目(2014-YY-014)
- DOI：10.13422/j.cnki.syfjx.2015050006
  中图分类号： R285.5
- 纸质出版日期：2015
- 稿件说明：
移动端阅览
谈聪, 薛世姣, 李博, 等. 基于方证对应理论的黄连解毒汤肠道吸收分析[J]. 中国实验方剂学杂志, 2015,21(5):6-10.

TAN Cong, XUE Shi-jiao, LI Bo, et al. Intestinal Absorption Analysis of Huanglian Jiedu Tang Based on Theory of Correspondence Between Syndrome and Prescription[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(5): 6-10.
谈聪, 薛世姣, 李博, 等. 基于方证对应理论的黄连解毒汤肠道吸收分析[J]. 中国实验方剂学杂志, 2015,21(5):6-10. DOI： 10.13422/j.cnki.syfjx.2015050006.

TAN Cong, XUE Shi-jiao, LI Bo, et al. Intestinal Absorption Analysis of Huanglian Jiedu Tang Based on Theory of Correspondence Between Syndrome and Prescription[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(5): 6-10. DOI： 10.13422/j.cnki.syfjx.2015050006.

摘要

目的: 基于方证对应理论研究正常和脑缺血病理状态下黄连解毒汤中指标成分肠吸收情况的差异性

探讨临床对症治疗脑缺血疾病的合理性。方法: 以黄连解毒汤中盐酸小檗碱、黄芩苷、栀子苷为检测指标

建立在体单向肠灌流模型

考察不同浓度黄连解毒汤在正常和脑缺血大鼠的肠吸收情况。结果: 与正常组比较

不同浓度黄连解毒汤中盐酸小檗碱、黄芩苷、栀子苷在脑缺血模型组大鼠不同肠段的肠吸收均有一定程度增加

其中盐酸小檗碱在十二指肠、空肠有显著性增加;黄芩苷在全部肠段的肠吸收均有显著性增加;栀子苷在空肠、回肠、结肠有显著性增加。结论: 黄连解毒汤主要药效成分在脑缺血大鼠的肠道吸收情况优于正常组

为该复方临床对症治疗脑缺血疾病的合理性提供实验依据

体现了中医方证对应理论。

Abstract

Objective: To investigate intestinal absorption characteristics of index components from Huanglian Jiedu Tang (HLJDT) in normal and cerebral ischemia states

and discuss rationality of HLJDT used in clinical to treat cerebral ischemia

basing on theory of correspondence between syndrome and prescription. Method: Taking geniposide

berberine hydrochloride and baicalin in HLJDT as indexes

in situ single pass perfusion model was established to investigate intestinal absorption characteristics of HLJDT with different concentrations in rats with normal and cerebral ischemia. Result: Compared with the normal group

absorption of geniposide

berberine hydrochloride and baicalin from HLJDT with different concentrations in all model group increased to some extent in different intestine segments.Berberine hydrochloride increased significantly in duodenum and jejunum.Baicalin increased significantly in the whole intestine.Intestinal absorption of geniposide increased significantly in jejunum

ileum and colon. Conclusion: Absorption of main active ingredients of HLJDT in the cerebral ischemia model group is better than that in the normal group

which supports rationality of widely use of HLJDT in the clinical application to exerting therapeutic effect and confirms theory of correspondence between syndrome and prescription.

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