石榴皮总多酚脂质体制备工艺参数的统计学分析

王占一; 戴博; 王玉海; 张立华; 李卓瓦; 毕海丹

doi:10.13422/j.cnki.syfjx.2015050033

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石榴皮总多酚脂质体制备工艺参数的统计学分析

药剂与炮制 | 更新时间：2024-01-04

- 石榴皮总多酚脂质体制备工艺参数的统计学分析
- Optimization of Preparation Process of Pomegranate Peel Polyphenols Liposomes
- 中国实验方剂学杂志 2015年21卷第5期页码：33-37
- 作者机构：
- 作者简介：
- 基金信息：
  
  国家星火计划项目(2012GA740049);山东省自然科学基金项目(ZR2013BL018)
- DOI：10.13422/j.cnki.syfjx.2015050033
  中图分类号： R283.6
- 纸质出版日期：2015
- 稿件说明：
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王占一, 戴博, 王玉海, 等. 石榴皮总多酚脂质体制备工艺参数的统计学分析[J]. 中国实验方剂学杂志, 2015,21(5):33-37.

WANG Zhan-yi, DAI Bo, WANG Yu-hai, et al. Optimization of Preparation Process of Pomegranate Peel Polyphenols Liposomes[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(5): 33-37.
王占一, 戴博, 王玉海, 等. 石榴皮总多酚脂质体制备工艺参数的统计学分析[J]. 中国实验方剂学杂志, 2015,21(5):33-37. DOI： 10.13422/j.cnki.syfjx.2015050033.

WANG Zhan-yi, DAI Bo, WANG Yu-hai, et al. Optimization of Preparation Process of Pomegranate Peel Polyphenols Liposomes[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(5): 33-37. DOI： 10.13422/j.cnki.syfjx.2015050033.

摘要

目的: 探究应用超临界CO2流体沉析技术制备石榴皮总多酚脂质体的工艺条件

为该制剂的工业化生产提供参考。方法: 以包封率为评价指标

通过Plackett-Burman试验筛选主要影响因素

利用最陡爬坡试验和Box-Behnken试验优选石榴皮总多酚脂质体的制备工艺。结果: 原药与膜材的质量比、反应温度和反应压力是影响总多酚脂质体包封率的显著性因素

最佳制备工艺条件为原药-膜材的质量比1:21.15

反应温度48.3 ℃

反应压力23.88 MPa。包封率实测值80.295%和预测值81.379%的偏差1.33%

有效粒度168.5 nm

Zeta电位-73.8 mV。结论: 该试验模型设计达到要求

工艺具有可行性。石榴皮总多酚脂质体体外释放速度缓慢

缓释效果明显

稳定性良好。

Abstract

Objective: To optimzie preparation process of pomegranate peel polyphenols liposomes by using supercritical CO2 fluid precipitation technology. Method: With entrapment efficiency as index

main factors were screened by Plackett-Burman test

preparation process of pomegranate peel polyphenols liposomes was optimized by steepest ascent test and Box-Behnken test. Result: Ratio of raw materials and membrane material

reaction temperature and pressure were significant factors

optimal preparation conditions was as following:ratio of raw materials and membrane material of 1: 21.15

reaction temperature at 48.3 ℃

reaction pressure of 23.88 MPa.The measured value and the predicted value of entrapment efficiency were 80.295% and 81.379%

effective size was 168.5 nm

Zeta potential was -73.8 mV. Conclusion: This test model meets requirements.In vitro release of pomegranate peel polyphenols liposomes is slow

its sustained release effect is obvious.

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