Objective: To investigate the effect of paeonol on ischemic arrhythmia and the expression of miRNA-1 of rats. Method: SPF SD rats were randomly divided into the normal group

the model group

the positive group (propranolol hydrochloride injection 2 mL·kg-1) and the paeonol group (6

3

1 mg·kg-1). The ischemic arrhythmia models were induced by injecting 5 μg·kg-1dose of aconitine intravenously. ECG changes of each group were recorded

premature beat (VPB) frequency and time for the first time

and ventricular tachycardia (VT) and ventricular fibrillation (VF) frequency and duration were recorded. Hearts were taken out on the end of the experiment

myocardial infarct sizes were measured

and the expression of miRNA-1 in myocardial cells was measured by RT-qPCR method. Result: Compared with the normal group

the ischemic arrhythmia was occurred

the frequencies of VPB

VT and VF increased

the VPB time for the first time shortened

the VT and VF durations increased

myocardial infarct sizes and miRNA-1 expression increased in the model group (P<0.05

P<0.01).The above indicators had good improvement in the paeonol group(P<0.05

P<0.01). Conclusion: Paeonol has an obvious effect in treating ischemic arrhythmias.