Objective: To observe the effect of Guanxin V mixture on acute myocardial infarction (AMI) after the ventricular remodeling

and investigate the mechanism of Guanxin V improving ventricular remodeling. Method: The model of acute myocardial infarction was established by left anterior descending coronary artery ligation. All of the rats were treated with Guanxin V mixture and Xuezhikang capsule for 4 weeks

The heart color measurement of ejection fractions (EF) value

fractional shortening (FS) value

calculate the left ventricular mass index and left ventricular surface area were observed

Western blot technique was used to detect the expression of Toll like receptor 4 (TLR4)

myeloid differentiation factor 88(MyD88)

nuclear factor-kappa B/p65 (NF-κB/p65) proteins. Result: Compared with the normal group and sham operation group

the EF

FS and expression of TLR4

MyD88

NF-κB/p65 in model rats were up-regulated

left ventricular mass index(LVMI) was decreased

the difference was statistically significant(P<0.05)

Compared with the model group

the EF

FS and expression of TLR4

MyD88

NF-κB/p65 in model rats were decreased

LVMI was increased

the difference was statistically significant(P<0.05).Expression of Guanxin V mixture was inversely proportional to the concentration of protein

the difference was statistically significant(P<0.05). Conclusion: Guanxin V mixture can inhibit TLR4/MyD88/NF-κB p65 signal pathway

this may be one of the mechanisms of improving ventricular remodeling.