Objective: To study the effects of the total alkali Sophora alopecuroids(TASa) on gastro antrum smooth muscle strips in diabetic gastroparesis rats and the possible mechanisms. Method: Forty wister rats were randomly divided into the control group(10 rats) and model group(30 rats).Rats in the model group were given intraperitoneal injection of streptozotoc to induce type I diabetic model. Weight

concentration of blood glucose

residual rate of gastric pigment and intestinal conduction velocity were detected. The isolated perfusion method was used to record amplitude

duration

area and contraction frequency of the gastro antrum smooth muscle in vitro. The strips of model group were divided into six groups:TASa group

TASa+1×10-7 mg·L-1 verapamil group

TASa+1×10-6 mg·L-1 phentolamine group

TASa+1×10-6 mg·L-1 benzhydramine group

TASa+1×10-6 mg·L-1 indomethacin group

TASa+1×10-6 mg·L-1 atropine group. The contraction effects of TASa were investigated. Result: TASa could increase gastro antrum smooth muscle's contraction amplitude

contraction duration and contraction area

had no effect on contraction frequency. Verapamil could inhibit the gastro antrum smooth muscle contraction of TASa

but atropine

phetolamine

benzhydramine and indomethacin had no contraction effect. Conclusion: TASa may activate calcium channel

increase calcium flow to the interior of the cell and increase gastro antrum smooth muscle's contraction.