Objective: To observe the curative effect of traditional Chinese medicine for fumigating -washing and enema combined with western medicine in treating hand-foot-mouth disease. Method: Two hundred and sixty patients with a clear diagnosis of hand-food-mouth disease were randomly divided into the observation group and the control group according to their ages by a random number table of 130 patients each. The patients in the control group received ribavirin intravenous drip (10 mg·kg-1) once daily and antibiotics when needed. On the basis of the control group

the patients in the observation group began to receive traditional Chinese medicine prescription of fumigating-washing treatment twice daily and enema treatment once daily within the first 24 hours of admission. The clinical efficacy

adverse reaction and complications of the two groups were observed. Result: The total effective rate in the observation group was 94.62%

which was obviously higher than 85.38% of the control group with statistically significant difference (P<0.05). The antifebrile time

erythra regression time and hospital stays in the observation group were shorter than those in the control group with statistically significant difference (P<0.05). Incidence of adverse reactions in the observation group was 4.62%

which was lower than 11.54% in the control group with statistically significant difference (P<0.05). Conclusion: Chinese medicine for fumigating-washing and enema combined with western medicine therapy is easy to accept and good adherence. Moreover

it has good absorption

short treatment course and takes effect quickly in treating hand-foot-mouth disease of children. It is worthy of clinical popularization and application.