Objective: To observe the additional effect of Chinese drugs for activating blood circulation and removing blood stasis (CDABCRBS) on the stability of coronary atherosclerotic plaque based on the standardized treatment with statins. Method: Totally 64 patients with stable coronary heart disease (CHD) were randomly divided into two groups (32 in each group)

the control group treated with statins

and the CDABCRBS group treated with compound tablet of red sage root based on statins treatment. After the 12-month treatment

the change of coronary artery stenosis rate

coronary artery calcium (CAC) scores and plaque number were observed by 64 row spiral CT. The serum lipid level and blood stasis syndrome (BSS) scores of the patients were also tested. Result: All patients had good improvment after treatment. Compared with the control group

the change of coronary artery stenosis rate decreased significantly (P<0.05)

CAC scores and plaque number decreased obviously in CDABCRBS group (P<0.05). In addition

the CDABCRBS group had superior effects in reducing the concentration of total cholesterol

increasing the concentration of high density lipoprotein cholesterol

and decreasing the atherosclerosis index

as compared to the control group (P<0.05). BSS scores in both groups decreased significantly after treatment (P<0.05)

while the improvement in the BSS scores showed no significant difference between two groups. Conclusion: Standardized statins combined with CDABCRBS therapy show better effect in atherosclerosis treatment and plaque stability in stable CHD patients

which reflect the advantage of integrated traditional Chinese and western medicines.