Objective: The aim of this study was to systematically summarize the syndrome differentiation and treatment thought of professor JIN Shi in treating chronic liver disease. Method: Medcase V3.2 storehouse and medical record national physician Maian data mining system was adopted to collect the typical cases of chronic liver disease treated by professor JIN Shi. Then frequency analysis and association rule analysis were used for data mining on symptoms

syndromes

pathogenesis and therapeutic principle. Result: There were 1 915 cases of chronic liver disease included

with chronic hepatitis B viral hepatitis the most disease (43.1%). Damp-heat-blood stasis-toxin and disorder of liver-spleen were the most frequent pathogenesis

accounting for 19.7% and 10.6% respectively;noxious heat stasis syndrome and damp-heat in liver-gallbladder syndrome were the most frequent syndrome

accounting for 22.6% and 19% respectively;regulating liver and activating spleen

clearing heat and damp

were the most common therapeutic principle

accounting for 12.2% and 8.2%

respectively. Conclusion: Noxious heat stasis syndrome and damp-heat in liver-gallbladder syndrome were the most frequent syndrome for chronic liver disease treated by professor JIN Shi

who valued the pathogenesis of damp-heat-blood stasis-toxin. The common therapies for chronic liver disease were regulating liver and activating spleen

and in the assistance of syndrome differentiation based adjuvant therapy

it can be applied to clear heat and damp

detoxify and disperse blood stasis

which can be generalized to clear

soothe

activate

dissolve and tonic.