Diabetic nephropathy (DN) is one of the most common microvascular complications of diabetes mellitus (DM)

which is also a primary causes of end-stage renal disease (ESRD).Its pathogenic factors and pathogenesis is very complicated with various reasons. In recent years

a large number of experimental studies have shown that flavonoids of Chinese herbal medicine have significant effect in preventing and treating DN. To better understand the progress of experiments in the prevention and treatment of DN by flavonoids

the paper searched the literature nearly 10 years

summarized in terms of flavonoids classification

experimental models

the role and mechanism. The study found:in the fight against DN

the most studied is the total flavonoids

there are okra factors

breviscapine

pueraria total flavonoids

fmcl Semen flavonoids

roem leaves

green thorn fruit flavonoids

guri geraniol total flavonoids

oxytropis falcate total flavonoids

but other flavonoids is relatively small. These studies are mainly animal experiments

basically using intraperitoneal injection of STZ models or high-fat and high-carbohydrate feeding rat model to made DN model

observed indicators in blood sugar

cholesterol

kidney function-based

molecular

cellular level indicator less. Through this study

we conclude that:how to develop herbal drug flavonoids medicine is the key issue

which is under the guidance of the theoretical system of Chinese medicine

combined with modern science and technology

multi-channel

multi-level and multi-level elaborate herbal flavonoids DN material basis of prevention efficacy

mechanism of action.