Objective: To optimize formula of Kangfuxin gastric floating tablets and provide a reference for development and utilization of Kangfuxin. Method: Kangfuxin gastric floating tablets were prepared by direct powder compression method.With in vitro floating properties and release as indexes

based on single factor tests

mixture design were adopted to optimize formula by taking dosages of hydroxypropyl methyl cellulose(HPMC)

crosslinking povidone(PVPP) and NaHCO3 as factors.HPLC was used to determine the content of amino acids with [0.1 mol · L-1 sodium acetate buffer solution(pH 6.5)-acetonitrile(93:7)]-[acetonitrile-water(80:20)]as mobile phase for gradient elution

detection wavelength of 254 nm and column temperature at 40 ℃. Result: Optimum formulation included 25% freeze-dried powder of Kangfuxin

28.38% HPMC K4M

13.38% NaHCO3

18.24% PVPP

14% microcrystalline cellulose and 1% magnesium stearate.Kangfuxin gastric floating tablets could float within (2±0.2) min and maintain for over 12 h

in vitro release of this tablets fitted zero-order kinetics model. Conclusion: These prepared gastric floating tablets show a good sustained-release and continual floating property

residence time of Kangfuxin in the stomach increases

it has great significance for treatment of peptic ulcer.