Objective: To discuss the effect of Gegen Qinlian Tang on periodontitis and atherosclerosis rats. Method: The rat model was induced by ligating the second molars of upper left jaw

feeding high fat diet and medications treatment as a complementary method. Thirty successful model rats were divided into the model group

the metronidazole treatment group (0.05 g · kg-1 · d-1)

the atorvastatin group (0.08 g · kg-1 · d-1)

the metronidazole combined with atorvastatin group

and the Gegen Qinlian Tang group (0.42 g · kg-1 · d-1) of 6 rats in each group. Another 10 rats were assigned to the normal group and feeding with the common forage. After 4-week treatment of the corresponding drug

the changes of periodontal tissue and abdominal aortic pathology were observed under light microscope

HE staining

respectively. The periodontal pocket depth and attachment loss detection

changes of blood lipid total cholesterol (TC)

triglyceride (TG)

low density lipoprotein (LDL)

high density lipoprotein (HDL) were detected. Result: Compared with the normal group

periodontal pocket depth and attachment loss

levels of lipid TC

TG

LDL increased significantly (P<0.05)

HDL level decreased significantly (P<0.05) in the model group. Compared with the model group

periodontal pocket depth and attachment loss

and lipid TC

TG

LDL levels decreased significantly (P<0.05)

HDL increased significantly (P<0.05) in all treatment groups. No significant difference was found between metronidazole combined with atorvastatin group and Gegen Qinlian Tang group. HE staining showed the destroyed periodontal inflammation

the separation of junctional epithelium and tooth surface

and the proliferation from epithelial to root. The deep tissue showed a large amount of inflammatory cell infiltration and bone trabecular sparse

alveolar bone surface visible bone resorption

alveolar ridge crest height reduced vertical absorption

periodontal ligament fibroblasts dimensional uneven thickness or fractured

arrangement disorder in the model group. These results had good improvement after treatment

and the results were better in the metronidazole combined with atorvastatin group and Gegen Qinlian Tang group. Conclusion: Gegen Qinlian Tang could improve the periodontal inflammation levels and reduce the blood lipid level of model rats. The results suggest that Gegen Qinlian Tang has a good therapeutic effect on periodontitis associated with atherosclerosis disease.