Objective: The aim of this article was to study the efficacy and safety of Aidi injection in combination with radiotherapy in treating non-small cell lung cancer (NSCLC). Method: Cochrane Library

PubMed

CBM

CNKI

VIP and WANFANG DATA were screened. The retrieval time was from the establishment time of each database to May 2014.Randomized controlled trials (RCTs) of Aidi injection in combination with radiotherapy in any language were included. Two researchers extracted data and assessed the literature quality separatedly

and made a Meta-analysis by RevMan 5.2 software. Result: 10 RCTs involving 678 patients entered the inclusion criteria. The meta-analysis showed that compared with pure application of radiotherapy

Aidi injection in combination with radiotherapy can enhance the short-term curative effect [OR=4.00

95%CI(2.86

5.60)

P<0.000 01]

and improve the quality of life [OR=4.99

95%CI(3.02

8.26)

P<0.000 01]

decrease the incidence of radiation pneumonitis [RR=0.46

95%CI(0.34

0.63)

P<0.000 01] radiation esophagitis [RR=0.49

95%CI(0.37

0.66)

P<0.000 01] and the bone marrow suppression [RR=0.51

95%CI(0.38

0.69)

P<0.000 01]. Conclusion: Aidi injection in combination with radiotherapy can not only enhance the short-term curative effect

but also improve the quality of life

and decrease the incidence of radiation pneumonitis

radiation esophagitis and bone marrow suppression. However

the quality of RCTs is low

so more clinical trials in high quality were needed to study.