Cell signal transduction system has become one of the hot research of diabetic nephropathy(DN) in recent years

as the initiating factor induced by high glucose

protein kinase C (PKC)signaling pathway activation and promote the research development of DN occurred

people pay more attention to the. Many studies show that the abnormal activation of PKC signaling pathway is involved in the occurrence and development of DN

and its important role has gradually established: activation of PKC signal pathway can significantly affect the hemodynamics

increased vascular permeability and extracellular matrix deposition

inhibiting the activity of Na+-K+-ATP and involved in cell proliferation. Opened up a new perspective and approach and the use of PKC inhibitors for the prevention and control of DN. The study confirmed that

Chinese herbs and their extracts

and some traditional Chinese medicine compound has protective effect on DM of rat kidney

also have good inhibitory effect on PKC signal pathway. But the existing research evidence that PKC signaling pathway inhibitors are usually nonspecific

and the side effect is big

but the specificity of PKC signaling pathway inhibitor is still in study

and so far no successful application to clinical precedent. Therefore

with the modernization of traditional Chinese medicine to accelerate

in-depth study of traditional Chinese medicine inhibits the activation of the PKC signaling pathway

has the important meaning to the signal path from intervention in the progress of DN. This paper will present the intervention of traditional Chinese medicine progress in PKC signaling pathway and DN research

for the future use of traditional Chinese medicine as PKC inhibitor for the prevention of DN and provide experimental and theoretical basis.