Prominent traditional Chinese medicine (TCM) doctors' effective prescriptions from experience are important carriers of development and inheritance of TCM academic.Some researches of prominent TCM doctors' prescriptions from experience were lacking evidence.The confirmations of compositions and indications were subjective.This paper proposed that a prominent TCM experiential prescription must come from clinical practice with cases as evidence.Under the guidance that ladder-like of progressive clinical evaluation method

a preliminary practice for discover of effective prescription has made by taking Xuantou Jiedu Yin from professor XUE Bo-shou as an example.The research included three steps

like preliminary finding

optimizing and verification.Optimization of effective prescription is the tread of ladder by observation research primarily

verification of effective prescription is the vertical surface of ladder based on validation study.This paper summarized that firstly should pay attention to accumulation of clinical cases in research process

including effective and invalid cases.Secondly

data from computer mining need man-machine communication.Thirdly

characteristics of TCM individualized differentiation should be retained

addition and subtraction of herbs in effective prescription is allowed in a certain rang.Lastly

improvement of research quality and method can promote transformation of achievement.