Objective: To optimize taste-modifying formula of compound Banlangen oral liquid for clinical application and promotion of this preparation. Method: On the basis of preliminary screening of taste-modifying agent.The best taste-modifying formula of compound Banlangen oral liquid composed of different sweeteners and aromatics was evaluated by fuzzy mathematics synthetic evaluation system. Result: Flavoring agent composed of sucralose and orange flavor had optimal taste-modifying effect.Optimum taste-modifying formula was as follows:added 1.5 g of sucralose and 0.5 g of orange flavor in 1 L of compound Banlangen oral liquid. Conclusion: Taste can be improved significantly than the original recipe (45% sucrose) by this new taste-modifying formula

which was optimized by fuzzy mathematics comprehensive evaluation.It is more suitable for children to take

and provides scientific basis for industrial production of compound Banlangen oral liquid.