Objective: To investigate effects of different amounts of lime on yield and quality of Salvia miltiorrhiza

and provid a reference for cultivation and autotoxicity ease of this herb. Method: With growth targets

yield and contents of seven kinds of active ingredients (salvianolic acid B

tanshinol

rosemary acid

tanshinone ⅡA

tanshinone Ⅰ

cryptotanshinone

dihydrotanshinone) as indexes

effects of different gradients of lime on growth and active ingredients of S. miltiorrhiza.HPLC was employed to determined the content of these seven components with mobile phase of acetonitrile-0.1% phosphoric acid water for gradient elution and detection wavelength at 280 nm. Result: Effects of adding lime on growth and biomass of S. miltiorrhiza did not reach significant levels.But with addition of lime

salvianolic acids substances and tanshinones substances presented a significant negative correlation trending

salvianolic acids first increased

then decreased;while tanshinones decreased first

further increased.Salvianolic acids increased significantly and tanshinones reduced significantly when added 60 g·m-2 of lime in continuous cropping soil or added 45 g·m-2 of lime in the new soil.But the amount of lime added up to 75 g·m-2

there were no significantly difference in these two types of components with the control group. Conclusion: Effects of adding lime on growth and biomass of S. miltiorrhiza do not reach significant levels;but with addition of lime

salvianolic acids and tanshinones presents competitive trend

this may be related to regulation of pH to key enzymes of secondary metabolites biosynthesis pathway.