Objective: This paper studies the effect of salvianolic acids on the related gene expression in the convalescent period of cerebral ischemia-reperfusion injury in diabetic rats

in order to explore the mechanism. Method: The Wistar rats were randomly divided into control group and model group. The single intraperitoneal injection of streptozotocin(STZ) 60 mg·kg-1 was used to establish diabetes mellitus. After the modeling

the rats were randomly assigned to sham group(SH)

ischemia-reperfusion group(IR) and salvianolic acids treatment group

six rats in each group. The focal cerebral ischemia-reperfusion model was used. The rats in the salvianolic acids treatment group would receive tail vein injection (21 mg·kg-1) after 3 hours of reperfusion

once per day for 14 days. The SH and the model group were injected with the same volume of saline. The related gene expression in the brain tissue was detected by the gene chip technique. Result: Fourteen days after the diabetic rats got a stroke

67 differential expressed genes were detected

among the 41 genes were up-regulated and 26 genes were down-regulated [P≤0.05

fold chang (FC)≥2.0];fourteen days after the treatment of salvianolic acids

compared with model group 64 differential expressed genes were detected

among the 45 genes were up-regulated and 19 genes were down-regulated (P≤0.05

FC≥2.0). Conclusion: Salvianolic acids exerts regulation on the rat's cerebral gene expression during the focal cerebral ischemia-reperfusion injury(CIRI)

which provides a new clue for the further study of the mechanism