Objective: To explore the effect of phenolic alkaloids of Menispermum dauricum (PAMD) on the learning and memory and hippocampal in Alzheimer's disease (AD) model mouse. Method: C57BL/6 mouse were randomly divided into control group

Piracetan group(620 mg·kg-1)

PAMD high-dose group(30 mg·kg-1)

PAMD medial-dose group (15 mg·kg-1)

PAMD low-dose group (7.5 mg·kg-1).By using intraperitoneal injection of D-galactose(180 mg·kg-1) in combination with microinjection of 10 μg incubated amyloidbeda protein1-42(Aβ1-42

2 g·L-1) into the dorsal blade of the dentale gyrus in the bilateral hippocampus of mouse an AD model mouse was induced. All the mice were ig administrated with drugs or water in the same voume for 28 days. The Morris water maze was used to observe the learning and memory ability. After the treatment all animals were sacrificed

morphology of hippocampus was observed. Biochemical methods were used to determine the content of Aβ and interleukin-6(IL-6) in the brain tissue. Result: Compared with the control group

model group latencies and swimming distances significantly prolonged(P < 0.05)

Aβ and IL-6 significantly increased(P < 0.05);compared with the model group

PAMD high-dose group and PAMD medial-dose group could significantly improve the learning and memory ability of model mouse(P < 0.05). In PAMD high-dose group and PAMD medial-dose group

the brain maintain normal morphological structure of nerve cells and the number of nerve cells was significantly increased

Aβ and IL-6 were significantly decreased(P < 0.05). Conclusion: PAMD could improve the ability of learning and memory of AD model mouse. PAMD can maintain normal morphological structure of nerve cells of AD mice. PAMD plays a certain role in the treatment of AD through inhibiting Aβ and IL-6.