Objective: Study on the expression of gastric tissue heat shock protein (HSP70) and HSP70 mRNA after exhaustive exercise in rats which pre-exercise supplement of mogroside(Mog)

to preliminary research the mechanism of mogroside. Method: Fifty healty male Sprague-Dawley rats were randomized into five groups

each consisting of 10 rats:the quiet group (NC)

the exercise group (ME)

the administration of Mog in low dose exercising group (MogL)

the administration of Mog in middle dose exercising group (MogM) and the administration of Mog in high dose exercising group (MogH). The rats were administrated by professional gavage once a day half an hour before exercising. This administration was continuously gaved six days in one week

and lasted for six weeks. The low

middle and high doses are respectively 100

200

400 mg·kg-1

while the rats in control group were administrated of pure physiological saline at the same dose. The rats were killed after 6-week training. The expression of gastric tissue protein HSP70 and HSP70 mRNA were measured according the corresponding kit method respectively. Result: The expression of gastric tissue protein HSP70 and HSP70mRNA were higher in exercise control group than these in NC group (P<0.05). The expression of gastric tissue protein HSP70 and HSP70 mRNA in MogL

MogM and MogH were higher than these in NC group and ME group (P<0.05

P<0.01). Conclusion: Supplement of Mog could improve the expression of gastric tissue protein HSP70 and HSP70 mRNA. This could play an important role to reduce gastric ulcer

promote recovery

growth of cell and development after injury.