Objective: To investigate the intervention of Feixianfang(FXF) in lung inflammatory reaction and fibrosis. Method: Rats were randomly divided into 7 groups:the sham operation group

model group

FXF high dose group

FXF middle dose group

FXF low dose group

the control group of Western medicine was divided into two groups:Losartan group

and prednisone group. Rats were given bleomycin(BLM) to induce model via tracheal intubation

3 mg·kg-1. Intragastric administration started from the next day after modeling. The rats were killed on 14 and 28 days after modeling

respectively. HE staining and Masson staining were applied to determine the degree of the alveolitis and pulmonary fibrosis.RT-PCR were applied to detect plasminogen activator inhibitor-1(PAI-1)

vascular cell adhesion molecule 1(VCAM-1) gene expression. Result: FXF middle dose could inhibit the degree of alveolitis(P<0.05). FXF middle dose can inhibit the degree of pulmonary fibrosis and the gene expression of VCAM-1

PAI-1(P<0.05). Conclusion: FXF improve pulmonary fibrosis by inhibiting expression of VCAM-1 and PAI-1 genet.