Objective: To study the effect of Zishen Qinggan Jiangtang compound(ZQJC) on glucose

protein tyrosine phosphatase 1B(PTP1B)expression

superexide dismutase(SOD)

malondialdehyde(MDA) and free fatty acide(FFA) in type 2 diabetic mellitus (T2DM) rats. Method: Ten rats were randomly selected as normal group

type 2 diabetes model was induced with high sucrose-fat diet and STZ ip for 30 mg·kg-1

rats were randomly divided into groups:model group

metformin(Met) group(0.14 g·kg-1·d-1

ig)

ZQJCL group(0.9 g·kg-1·d-1

ig)

ZQJCM group(1.8 g·kg-1·d-1

ig)and ZQJCH group(3.6 g·kg-1·d-1

ig)

10 rats in each group. fasting blood glucose(FBG) was detected at 2nd week and 4th week

and the level of SOD

MDA

FFA in the rats' serum and PTP1B expression in liver at 4th week were measured after the treatment. Result: Compared with the normal group

the blood glucose levels of model group were increased (P<0.01)

PTP1B expressions in liver of model group were increased (P<0.01).After treatment

compared with model group

ZQJC group could obviously decrease the levels of FBG

MDA and FFA (P<0.05

P<0.01)

improve SOD activity (P<0.05) and inhibit the PTP1B expression in liver. Conclusion: ZQJC has the effect of regulating glucose metabolism of the T2DM rats

inhibition of oxidative stress and PTP1B expression in liver could be one of the mechanisms.