Objective: To investigate the estrogenic effect of the incompatibility of Veratrum nigrum and Panax gingseng on immature mouse. Method: One hundied and twenty female Kunming mice

were randomly divided into 12 groups:the normal group

estrogen receptor antagonist (ICI) group (5 mg·kg-1)

the V. nigrum (VT) group

(0.045 g·kg-1)

the low-

middle-and high-dose P. gingseng (GS) groups

(12

18

24 g·kg-1)

ICI+low-dose GS group(ICI 5 mg·kg-1+GS 12 g·kg-1)

ICI+middle-dose GS group (ICI 5 mg·kg-1+ GS 18 g·kg-1)

ICI+high-doses GS group (ICI 5 mg·kg-1+GS 24 g·kg-1)

VT +low-dose GS group (VT 0.045 g·kg-1+GS 12 g·kg-1)

VT+middle-dose GS group (VT 0.045 g·kg-1+GS 18 g·kg-1)

VT+high-dose GS group (VT 0.045 g·kg-1+GS 24 g·kg-1). The uterus index

estradiol (E2)

luteinizing hormone (LH)

follicle stimulating hormone (FSH)

and the difference between uterine and vaginal histopathology were observed after 5 days. Result: Compared to the normal group

the uterus index increased (P<0.05)

E2 increased (P<0.05

P<0.01)

levels of LH and FSH decreased (P<0.05) in all doses of GS groups. Meanwhile

the growth and development of the uterus and vagina were promoted. While GS used with VT

uterus index decreased (P<0.05

P<0.01)

levels of E2 notably decreased (P<0.05

P<0.01)

levels of LH and FSH increased (P<0.05

P<0.01)

and the degree of uterus and vagina atrophy was increased. Conclusion: VT could impair the estrogenic effect of GS in a certain dosage.