Objective: This study aimed to compare the clinical efficacy and safety of Tanreqing injection

Xiyanping injection and Xuebijing injection in adjuvantly treating children with acute suppurative tonsillitis. Method: A retrospective study from May 2012 to May 2014

according to the types of traditional Chinese medicine injections used

338 children with a confirmed diagnosis of acute suppurative tonsilltis were divided into four groups (group A

B

C and D). Group D was given antimicrobial agents alone. Based on the group D

group A was given Tanreqing injection in a dosage of 0.3-0.5 mL·kg-1·d-1

with 100 mL 5% glucose injection in static drop once a day. Group B was given Xiyanping injection in a dosage of 5-10 mg·kg-1·d-1

with 100 mL 5% glucose injection in static drops once a day. Group C was given Xuebijing injection in a dosage of 1 mL·kg-1·d-1

in the maximum dosage less than 20 mL·d-1

with 100 mL 0.9% Sodium Chloride injection in static drops once a day. The clinical efficacy and safety of the four groups were observed and the statistical analysis were conducted. Result: The curative rate and total effective rate in the four groups were 29.07%

21.25%

37.63%

15.00% and 83.72%

72.15%

92.47%

56.25%

respectively. The time of clinical signs and symptoms recovery in group C was the shortest

while in group D it was the longest. The statistical test results revealed that group D was significant different from group A

B and C (P<0.05)

but there were no significant differences between group A and group B

group A and group C. And the rate of ADR in group D was the least

but there were no significant differences in group A

B and C. Conclusion: Among the three TCM injections

xuebijing injection are the highest in total effective rate

the shortest in the time of drug treatment

but with the highest in the infusion phlebitis. So we suggest that it should be closely monitored during treatment.