Objective: To observe the clinical effect of Yiqi Huoxue formula combined omeprazole in treating patients with peptic ulcer

and to investigate its influence on trefoil factor 2 (TFF2) and vascular endothelial growth factor (VEGF). Method: One hundred and three patients with peptic ulcer were randomly divided into the observation group (52 cases) and the control group (51 cases). The patients in the control group received 20 mg omeprazole capsules orally twice daily. On the basis of the control group

the patients in the observation group added Yiqi Huoxue formula. All patients in both two groups received 3 months of treatment. Scores of traditional Chinese medical (TCM) symptom were evaluated. Serum TFF2

VEGF levels and 1-year recurrence rate after 3-month treatment were observed. Result: The total effective rate of TCM symptom in the observation group was 94.23%

which was higher than that of 82.35% in the control group with statistically significant difference (P<0.05). The total effective rate of gastroscope in two groups was 82.69% and 86.27%

while there were no statistically significant differences between the two groups. After 3-month treatment

the total symptom-score of both groups decreased significantly (P<0.05)

and the result was lower in the observation group (P<0.05). The expression levels of TFF2

VEGF were obviously increased in two groups

but the results were higher in the observation group (P<0.05). After 3-month treatment

the negative rate of Helicobacter pylori infection in two groups was 73.5% and 65.6%

and there were no statistically significant differences between two groups. 8 cases got the standard of relapse in the observation group and 22 cases in the control group within one year

and there were statistically significant differences between two groups (P<0.05). Conclusion: Yiqi Huoxue formula combined omeprazole has significant effect in treating peptic ulcer

and it could improve the expression levels of TFF2

VEGF

reduce the recurrence rate within one year.